Attempted rescue of circling mice by hair cell-specific expression (Myo7a promoter) of tmie transgene
نویسندگان
چکیده
منابع مشابه
Over-expression of myosin7A in cochlear hair cells of circling mice
Circling mouse (C57BL/6J-cir/cir) deleted the transmembrane inner ear (Tmie) gene is an animal model for human non-syndromic recessive deafness, DFNB6. In circling mouse, hair cells in the cochlea have degenerated and hair bundles have become irregularity as time goes on. Tmie protein carries out a function of the mechanoelectrical transduction channel in cochlear hair cells. Myosin7a (MYO7A) p...
متن کاملIntroduction of Transmembrane Inner Ear (tmie) Gene Can Recover the Hearing Impairment and Abnormal Behavior in the Circling Mouse
The spontaneous mutant circling mouse (cir/cir) shows a circling behavior and hearing loss. We produced transgenic mice overexpressing the causative gene, transmembrane inner ear (tmie), for the phenotypic rescue of the circling mouse. Through the continuous breeding with circling mice, the cir/cir homozygous mice carrying the transgene (cir/cir-tg) were produced. The rescued cir/cir -tg mice w...
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ژورنال
عنوان ژورنال: Medycyna Weterynaryjna
سال: 2017
ISSN: 0025-8628
DOI: 10.21521/mw.5744